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Yes, you can sell Bitcoin and other supported cryptocurrencies directly through Ledger Live Desktop by using the integrated exchange feature. Make sure your Ledger device is updated and follow these steps:

1. Connect your Ledger device and open Ledger Live.

2. Navigate to the "Accounts" tab and select the account with the crypto you wish to sell.

3. Click on "Sell" and choose the exchange you want to use. Follow the on-screen instructions to complete the transaction.

Remember, transactions may include fees and require verification steps, depending on the exchange you select.